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DTSTART;TZID=America/Los_Angeles:20231106T120000
DTEND;TZID=America/Los_Angeles:20231106T133000
DTSTAMP:20260507T152604
CREATED:20230925T174221Z
LAST-MODIFIED:20231107T232918Z
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SUMMARY:Michael Wells - Exploration of human genetic and phenotypic diversity through cell villages
DESCRIPTION:Exploration of human genetic and phenotypic diversity through cell villages\nMichael Wells\nAssistant Professor\, UCLA Department of Human Genetics\nHuman genome variation contributes to diversity in neurodevelopmental outcomes and vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require scalable approaches. Here\, I will describe a ‘‘cell village’’ experimental platform we used to analyze genetic\, molecular\, and phenotypic heterogeneity across neural progenitor cells from 44 human donors cultured in a shared in vitro environment using algorithms (Dropulation and Census-seq) to assign cells and phenotypes to individual donors. Through rapid induction of human stem cell-derived neural progenitor cells\, measurements of natural genetic variation\, and CRISPR-Cas9 genetic perturbations\, we identified a common variant that regulates antiviral IFITM3 expression and explains most inter-individual variation in susceptibility to the Zika virus. We also detected expression QTLs corresponding to GWAS loci for brain traits and discovered novel disease-relevant regulators of progenitor proliferation and differentiation such as CACHD1. The village approach provides scalable ways to elucidate the effects of genes and genetic variation on cellular phenotypes\, and can help elucidate the mechanisms guiding brain development and associated diseases.
URL:https://bec.ucla.edu/event/michael-wells-exploration-of-human-genetic-and-phenotypic-diversity-through-cell-villages/
LOCATION:352 Haines Hall
CATEGORIES:2023,Past Presentation,Presentation
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DTSTART;TZID=America/Los_Angeles:20231113T120000
DTEND;TZID=America/Los_Angeles:20231113T133000
DTSTAMP:20260507T152604
CREATED:20230925T174330Z
LAST-MODIFIED:20231115T031023Z
UID:6864-1699876800-1699882200@bec.ucla.edu
SUMMARY:Zarin Machanda - Social aging in wild chimpanzees
DESCRIPTION:Social aging in wild chimpanzees\nZarin Machanda\nTufts University\, Departments of Anthropology and Biology\nHumans are living longer lives than ever before and so it is critical to understand the process of aging. It has become increasingly recognized that successful aging is not just about physical health but also about our social lives. Chimpanzees are our closest living relative and lead long and complex lives making them an ideal model to better understand our own patterns of social aging. In this talk\, Dr. Machanda will discuss the patterns of social aging in wild chimpanzees from her decades-long research project studying the Kanyawara chimpanzees living in Kibale National Park\, Uganda.
URL:https://bec.ucla.edu/event/zarin-machanda-social-aging-in-wild-chimpanzees/
LOCATION:352 Haines Hall
CATEGORIES:2023,Past Presentation,Presentation
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20231127T120000
DTEND;TZID=America/Los_Angeles:20231127T133000
DTSTAMP:20260507T152604
CREATED:20230925T174614Z
LAST-MODIFIED:20231128T185939Z
UID:6867-1701086400-1701091800@bec.ucla.edu
SUMMARY:Theo Samore - Traditionalism\, pathogen avoidance\, and competing tradeoffs during a global pandemic
DESCRIPTION:Traditionalism\, pathogen avoidance\, and competing tradeoffs during a global pandemic\nTheo Samore\nUniversity of Otago\nIndividuals vary in the extent to which they embrace their society’s traditions\, as well as in the perception of threats as salient and necessitating mitigation. Traditionalism and threat sensitivity may be linked if—over evolutionary time—traditions offered avenues for reliably addressing threats\, either through instrumental and/or ritual and cooperative benefits. Alternatively\, if traditionalists are attuned to group-destabilizing threats\, they may also exhibit greater threat sensitivity in certain domains. These possibilities – which are not mutually exclusive – suggest that greater traditionalism may associate with stronger mitigating responses toward some threats. However\, threat-avoidance motivations can conflict with competing priorities and epistemic commitments in the real world. The COVID-19 pandemic represented a moment in time in which people across the world undertook costly threat-mitigating behaviors\, providing an important test of the traditionalism-threat avoidance relationship under complex real-world conditions. We investigated the relationship between COVID-19 precautions\, traditionalism\, and perceptions of competing tradeoffs in both the U.S. and a large 27-country cross-cultural sample. Results indicated that\, across study sites\, traditionalism tended to positively correlate with behaviors intended to mitigate the threat of COVID-19. Further\, despite possible epistemic conflict between religion and science\, individuals tended to report engaging in both scientifically and religiously rooted precautions. Nevertheless\, at some study sites\, the relationship between public health precautions and traditionalism was suppressed by competing priorities\, such as lower trust in scientists and greater concerns about personal liberties.
URL:https://bec.ucla.edu/event/theo-samore-traditionalism-pathogen-avoidance-and-competing-tradeoffs-during-a-global-pandemic/
LOCATION:352 Haines Hall
CATEGORIES:2023,Past Presentation,Presentation
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