BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Center for Behavior, Evolution, and Culture - ECPv6.15.20//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-ORIGINAL-URL:https://bec.ucla.edu
X-WR-CALDESC:Events for Center for Behavior, Evolution, and Culture
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/Los_Angeles
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20210314T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20211107T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20220313T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20221106T090000
END:STANDARD
BEGIN:DAYLIGHT
TZOFFSETFROM:-0800
TZOFFSETTO:-0700
TZNAME:PDT
DTSTART:20230312T100000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0700
TZOFFSETTO:-0800
TZNAME:PST
DTSTART:20231105T090000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/Los_Angeles:20220110T120000
DTEND;TZID=America/Los_Angeles:20220110T133000
DTSTAMP:20260504T110049
CREATED:20220102T175847Z
LAST-MODIFIED:20220117T225052Z
UID:6390-1641816000-1641821400@bec.ucla.edu
SUMMARY:Ed Hagen - Homo medicus: The transition to meat eating\, increased pathogen pressure\, and the constitutive and inducible use of pharmacological plants in Homo
DESCRIPTION:Homo medicus: The transition to meat eating\, increased pathogen pressure\, and the constitutive and inducible use of pharmacological plants in Homo\n\n\n\nEdward H. Hagen\, Aaron D. Blackwell\, Aaron D. Lightner\, Roger J. Sullivan\n\n\n\nClick here for link to manuscript pre-print\n\n  \nThe human lineage entered a more carnivorous niche 2.6 mya. A range of evidence indicates this increased zoonotic pathogen pressure. This evidence includes increased zoonotic infections modern hunter-gatherers and bushmeat hunters relative to others living in the same environments\, exceptionally low stomach pH compared to other primates\, human-specific down-regulation in ANTXR2 that would have protected against increased exposure to zoonotic anthrax\, exceptional human immune responses to LPS compared to other primates\, and other divergent immune genes. These all point to change\, and likely intensification\, in the disease environment of Homo compared to earlier hominins and other apes. At the same time\, the brain\, an organ in which inflammatory immune responses are highly constrained\, begins to increase\, eventually tripling in size. \n\nWe propose that the combination of increased zoonotic pathogen pressure and the challenges of defending a large brain and body from pathogens across what would eventually become the longest lifespan of any mammal\, selected for intensification of the self-medication strategies already in place in apes and other primates\, resulting in a variety of plant-based pathogen defenses. In support\, there is evidence of medicinal plant use by hominins in the middle Paleolithic\, and all cultures today have sophisticated\, plant-based medical systems\, incorporate plant components high in secondary compounds (spices) into food\, and regularly consume psychoactive substances that are harmful to helminths and other pathogens in the CNS and other tissues. The computational challenges of discovering effective plant-based treatments\, and the economic challenges of benefiting from costly-to-acquire medical knowledge that would be more often useful to others than oneself\, were selection pressures for increased cognitive abilities and unique exchange relationships in Homo. In the story of human evolution\, which has long featured hunters\, shamans and healers had an equal role to play.
URL:https://bec.ucla.edu/event/ed-hagen/
CATEGORIES:2022,Past Presentation,Presentation
END:VEVENT
END:VCALENDAR