Abstract: Models of the social determinants of health have proliferated in recent years across multiple disciplines. Yet, this surge in the literature within a small timeframe has led to ambiguities. Particularly unclear are the social determinants that should be focused upon in clinical applications. These and other important questions remain unresolved. For instance, how do cultural norms, political conditions, and biological mechanisms interact to affect health? How are developmental trajectories facultatively calibrated to environments, and how do these trajectories later shape health outcomes? To address these questions, I work from a biocultural anthropology and evolutionary perspective that integrates evolutionary, cultural, and biological theories that offer insights into health disparities. I will describe my work that examines how pregnant Filipina and Latina American mothers respond to stress from their socio-political environment, pathways for embodiment, and my plans for extending this work.